E cadherin

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E cadherin Business claims

Open Category: Medical Genetics Life Sciences Biology Diseases Cellular Cell Biology Natural Sciences Genetics

Prot cadherin (Pcdh) is a cadherin with new properties and is an editorial summary

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INTRODUCTION / Primal cadherin editing

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Brain cells also have molecular diversity, they are able to identify and distinguish each other, to establish the correct link, it is because of that string of different identity passwords. While the codon is a molecule called "cadherin." They are called "native cadherins" because these proteins are calcium-dependent adhesion molecules distributed on the surface of nerve cell membranes.

Composition / Original cadherin editing

E cadherin, like typical cadherin, has three parts: extracellular domain, plasma membrane region and intracellular domain. Pcdh, Pcdh, and Pcdh are found in the subfamily of cadherin.

Physiological function / procalinin editing

E cadherin The original cadherin molecules can not only serve as adhesion molecules to enhance synaptic connections, but also as receptors in the signal transduction process play a role.

There are 53 genes in the brain, the original cadherin gene, through gene expression and regulation, resulting in the original cadherin. This is like a playing card, each card has a code. When you create a password for a nerve cell, not every card is played, just a dozen of them. These cadherins form molecular groups that give each nerve cell a different "identity." When the nerve cells "connector", the "password" is like "signal", only the signal on the right, the relevant nerve cells will link to each other, the exercise function, thus establishing complex neural network.

The primary cadherin plays an important role in the development of the brain neural network. If knockdown or down-regulation of cadherin, the abnormal development of nerve cells can be induced and the apoptosis is induced. In the original cadherin family, the original cadherin alpha gene is autosomal susceptibility gene, this gene defects easily lead to cadherin alpha disorders, susceptibility to autism. The research on the cause of the cipher of the nerve cell is helpful to reveal the molecular mechanism of the mental illness. In the future, it may be possible to control the nerve cell coding by genetic manipulation to benefit the human mental health.

Study / editing of primary cadherin

Wu Qiang (center) in the laboratory to do the relevant experiments Shanghai Jiao Tong University in December 5, 2012 announced that Shanghai Jiao Tong University System Biomedical Research Institute Wu Qiang team found that the development of the brain expression of cadherin expression regulation mechanism, and clarified the original calcium The molecular mechanism of cell - specific expression of protein family in brain. Wu Qiang team found two magical "key" - insulator binding protein CTCF and chromosome adhesion protein Cohesin. Through these two "keys", enhancers of the original cadherin gene promoter attracted to form a ring, ring connected to form transcriptional cadherin in the transcription center.

Further research on the basis of this result will help people understand the mechanism of complex neural network formation and promote the study of the pathogenesis of brain diseases such as brain tumor, schizophrenia and autism. Related results in the November 30, 2012 boarded a comprehensive international top academic journals, "Proceedings of the National Academy of Sciences."

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References [1] ^ Brain cells how to link 53 genes to write the password Date: 2012-12-10 [2] ^ Chinese original network: the original cadherin C_3 (Protocadherin gamma C 3) intracellular fragment cloning and expression reference 2011-12-11 [4] ^ The mechanism of protein expression regulation in the development of the brain Research on the mechanism of protein expression regulation in the brain development of scientists to study the mechanism of expression regulation of the original brain cadherin, Important progress has been made [map] Quote Date: 2012-12-10 Open Category Expand Collapse All Expand All Collapse All Expand All Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all Expand all Collapse all ] [Delete] [Delete] [Delete] [Delete] [Delete] Synonyms Expand Collapse Synonyms

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